Graeme Laver, one of Australiaâs greatest influenza research scientists, died after collapsing en route to an influenza meeting in Portugal in September 2008. Graeme was born in Victoria, educated at Ivanhoe Grammar School and graduated from the University of Melbourne in biochemistry. He received his PhD in biochemistry at the University of London before returning to the John Curtin School of Medical Research at the Australian National University (ANU) in 1958. After the Burnet School at the Walter and Eliza Hall Institute in Melbourne changed its focus from influenza to immunology, the influenza research program moved with Frank Fennerâs group to ANU, where it was anchored by Stephan Fazekas de St. Groth. There the pioneering influenza work of Sir MacFarlane Burnet continued, with Graeme Laver as biochemist and Stephan Fazekas as the mathematical modeler of virus neutralization. I (Rob Webster) joined the group in 1959 to carry on the virus neutralization studies. To elucidate the subunit structure of influenza viruses, Graeme gently dissociated the lipid bilayer of the virus with the mild detergent sodium deoxycholate and established the basis for the first Australian subunit influenza vaccine. Before that accomplishment, only intact inactivated influenza vaccines had been used in Australia and they were considered undesirably reactogenic. Studies first in rabbits and then in children established the proof of principle for the vaccine. The ANU paid Laver and myself 10 shillings each for the patent rights. Australian subunit influenza vaccines have been further improved, but the fundamental principle established by Laver remains the same: that the proteins must be kept in their native conformation for the vaccine to be effective. Further studies with Robin Valentine of the National Institute of Medical Research at Mill Hill, London, established the morphology of the hemagglutinin (HA) and neuraminidase (NA) subunits by electron microscopy, and later work with Nick Wrigley produced the first electron microscopy images of antigen-antibody complexes. After the emergence of the Asian influenza pandemic in 1957 the influenza community, led by Martin Kaplan of the World Health Organization (WHO), began searching for the origins of influenza pandemics. During a fishing trip to the Southeast coast of Australia, near Batemanâs Bay, New South Wales, Laver and I found the beaches littered with dead mutton birds (Puffinus pacificus). Knowing that A/Tern/South Africa/61 (H5N3) influenza virus had been isolated from seabirds, we speculated that the mutton birds might have been killed by an influenza virus. In 1970, serological studies of mutton birds on the Great Barrier Reef of Australia found the first evidence of human N2 neuraminidaseâinhibiting antibodies, and in 1973 influenza viruses were isolated for the first time from wild migratory seabirds. These findings provided the first links in the chain of evidence that subsequently showed that the migratory aquatic birds of the world are the natural reservoirs of all influenza A viruses. Studies on the structure of influenza virus neuraminidase began with Graemeâs keynote paper in 1978 on crystallization of the heads of the human N2 neuraminidase molecule (Virology 1978; 96: 78â87). These and subsequent studies culminated in the resolution of the three-dimensional structure of the neuraminidase, with Peter Colman and Jose Varghese. With this information, Mark von Itzstein was able to design the first structure-based anti-influenza drug, zanamivir (Relenza). Further development using NA crystals provided by Graeme led to the development of the orally available anti-influenza drug oseltamivir (Tamiflu). The WHO Global Influenza Surveillance Network was established in 1952 to keep up with antigenic drift in influenza viruses and to recommend changes in vaccine strains to stay abreast of antigenic variation. However, there was no fundamental understanding of the mechanisms involved until Graeme Laver began peptide mapping of the hemagglutinin (HA) molecule and provided evidence of multiple antigenic determinants on HA spikes (Virology 1974; 59: 230â244). The advent of monoclonal antibodies by Georges Kohler and Caesar Milstein and their use to select influenza virus escape mutants, together with sequence analysis of the HA molecules (Virology 1979; 98: 226â237), established that a single amino acid change in the HA would allow the influenza virus to escape neutralization. Antigenic mapping of the HA and NA molecules soon followed and, ultimately, establishment of the antibody binding domains and visualization of the epitopes on the NA subunits (Nature 1987; 326: 358â363). Thus, the mechanism of antigenic drift in influenza and the epitopes involved were elucidated thanks to the seminal work of the Laver laboratory. Graeme Laver had a sense of adventure in all aspects of his life, from family to friends to research, and was always a free spirit who was willing to challenge bureaucracy when they âgot it wrongâ. He was an avid skier, mountaineer, gardener and axeman. In later life, his scientific passion was the production of perfect crystals of NA through studies in zero gravity on the Russian MIR space station and crystallization chambers set up in every laboratory he visited. Some of the most beautiful crystals were the N9 neuraminidase of an influenza virus isolated from a noddy tern on the Great Barrier Reef. Photographs of these crystals appeared on the covers of many scientific journals, and Graeme and photographer Julie Macklin were awarded the Nikon âSmall Worldâ prize in 1987. In addition to influenza, Graeme made contributions to our knowledge about adenoviruses, sialidases and paramyxoviruses. His multiple scientific achievements were recognized by his election to the Royal Society of London in 1987 and by co-receipt of the Australia Prize with Peter Coleman, Mark von Itzstein and Paul Janssen in 1996. In its efforts to prepare for an influenza pandemic and to identify the best options for controlling seasonal influenza, the global community owes a very special debt to Graeme Laver. The current strategies for control of both pandemic and seasonal influenza, the stockpiles of anti-influenza drugs and prepandemic vaccines are products of his lifeâs work. His final mission was to have anti-influenza drugs made available over the counter so that every household could have an immediate supply in the face of a pandemic. He argued that this option would have no effect on the emergence of resistance and could save millions of lives in the event of infrastructure failure. New Zealand has taken the lead in following his visionary advice.
Abstract The Canadian province of British Columbia has been widely recognized as the North American leader in employing Design, Build, Finance Operate publicâprivate partnerships to create new public infrastructure. Canada is one of the most decentralized federations in the world. Provinces exercise considerable autonomy and have powerful revenue raising power at their disposal. Although Canadian local governments are generally seen as substantially inferior to the two senior levels of government, those in British Columbia have in fact managed to achieve quite a bit of autonomy due to non-constitutional factors. Large infrastructure projects, for which municipalities and other local government agencies must look to the province for financial support are among the most controversial of issues within the provincialâlocal government relationship. The introduction of publicâprivate partnerships represents a classic example of a political entrepreneur changing the rules of the game to favour their desired outcomes. In this case, a government leader determined to pursue an infrastructure program that the province lacked the capital to support and the re-structuring of the state along New Public Management lines. However, even though the rule change favoured the Premier's immediate goals, and allowed him to over-ride much local objection, it can be argued that in the long run neither local governments nor the province have necessarily gained in power by changing the rules of the game. In keeping with the general tenants of the New Public Management, the introduction of publicâprivate partnerships has given precedence to technocratic forms of knowledge, especially those involved with finance and accounting, with the aim of pursuing public goals in the most âeconomically efficientâ manner possible. The flip side is that democratic input is strictly limited to the initial question as to whether or not a project is desirable, not how it can be best achieved or whether, once underway, it still represents a wise move. As a result, if there are any real winners in terms of autonomy, it has been senior public managers at both the provincial and local level and their financial and accounting advisors. These actors have had the range of issues for which they are accountable markedly simplified when it comes to major infrastructure projects, even as the complexity of such projects are increased by the use of publicâprivate partnerships. Evidence is drawn from government documents, news accounts and interviews conducted by the author with senior managers, politicians and appointed board members of local government organizations (a quasi-governmental agency and a regional municipality's transit authority) as well as a provincial ministry, which acts as a control case. By employing three cases within the same province and the same time-frame, many of the contextual factors that can confound a study of this sort have been held constant for the purpose of comparison.
The paper considers a three-tier credit chain consisting of a bank, a logistic company and a retailer. The paper analysis the following outsourcing structure implemented by top-tier bank: inhouse consignment, under which the bank signs independent contracts with the logistic company and the retailer. Under the assumption that the logistic company cannot change its decision, the paper investigates the equilibrium behavior of the decentralized credit chain with non-cooperation newsvendor under demand uncertainty. The model includes the case of a risk-neutral bank offering loan to a noncooperative risk-neutral retailer who mortgages its inventory to the bank to finance more inventory. The retailer faces a random demand in a single sales season as in the classical newsvendor problem. By game theorem, the paper gives the optimal loan to value to retailers with different initial capital.
:This paper aims to show how state intervention within the European Monetary Union can have positive effects not only on growth but also on public balances and debt. The relation between centralized monetary policy and decentralized fiscal policy partly solves the lack of coordination between the two. Each time a fiscal expansion in an EU country is not accompanied by a Central Bank interest rate increase, the expansionary effect of public spending, initially financed through the emission of public bonds, will be reinforced by endogenous money creation due to the increase in growth. The final result, if growth exceeds the rate of interest, is not only an increase in equilibrium income, but also a reduction in debt.
Autonomous Decentralized System (ADS) has been making progress in these 31 years since it was proposed in 1977. During these long years in the rapidly advancing computer and communication technologies, the ADS concept has not been changed but its technologies have been growing in accordance with the change and diversity of the social, economical and personal requirements and through the globalization of the market and the restructuring organizations. The ADS technologies are system-atized to cover all processes of system design, operation, maintenance and modification. This paper reviews the work done in fields of ADS in past 31 years from not only technological perspectives, but it also encompasses users requirements and value, system design, industrial activity, academic activity and standardization [1]-[26]. Moreover the new directions of the ADS are suggested.
The topic of the above title has vividly interested the author for many years. Regretfully, the issues at stake have not changed for the last 25 years. As proof of this - and on purpose - references dug up and quoted are only those published before 1986. The end result has been the (re)construction of a scenario that has been stubborn to change and that looks into most of the burning questions of then and now pertaining to the title.The materials here presented are an informal, non-systematic review of the literature on the ethical, ideological and political implications of health as a science and as a praxis. The materials here collected are, in a way, "out of the box" and, in the author's view very needed. The article sheds some light on the major issues at the core of this universal discussion that - whether we like it or not - was and continues to be at the very base of our daily work as health professionals.
The design of the decentralized co-operative governance system, conditioned and \nregulated by the South African constitution is of critical importance for policy design and \nimplementation. The division of powers falls within a unitary form of government. This \nstudy, which is about the processes, mechanisms and modalities of public policies \ndesign and implementation uses the public finance and health sectors, as a case study \nor lens through which policy design and implementation is examined within a \ndecentralized cooperative governance system. The study is per se not about the public \nhealth system, but rather a review and an analysis about how the decentralization and \ncooperative governance nature, practice and dynamic of government system, influences \nand condition the policy processes and practice on finance and health, separately and \ncollectively within the public health system. \nIn its attempt to unbundle the health function, but also reform the public health system, \ncentral and provincial governments have introduced a number of reforms. These reforms \nwere ostensibly driven by different policies and programmes originating either from the \npublic finance or public health sectors with significant consequences for the provinces. \nMoreover, these different policies also outlined structural and functional responsibilities \nand authority among the central and provincial government departments. The \nimplementation of these policies was at times based on different interpretations of policy \ndesign and implementation responsibilities and authority between the central and \nprovincial governments within co-operative governance system. \nThe argument of this study is that despite intentions implicit to public policy, co-operative \ngovernance system is contested at a central government level within the public health \nsystem, as well as between levels of government and the public health and finance \nsectors. This dissertation explores the nature of the relationship between the central and \nprovincial governments by exploring co-operative governance in the health sector on \npolicy and financing processes and mechanisms. The central question is how does \ndecentralized co-operative governance really work in the public health system? \nA case study method was used to conduct this research. Data was collected over a four \nand half year period using a variety of data collection methods, including semi-structured \nin-depth interviews; documents and reports analyses; policy content review and \nanalyses; and revenue and expenditure reviews and analyses. \nThe studyâs findings are: \na) the functional and structural decentralization of policy-making and implementation \nwithin the co-operative governance system contributes to undermining the cooperative \ngovernance relationship between the public finance and health sector and \ncentral and provincial governments; \nb) the central government is using its overriding powers to âimpose co-ordinated \nsolutionsâ to problems within the co-operative governance system, leading to \nsituations where âimposed co-ordinationâ is considered as âco-operative governanceâ; \nc) the theory provides a classical distinction between state control, supervision and \ninterference models. This dissertation shows that, depending on the policy context \nand circumstances, the uniqueness of South Africaâs co-operative governance \nsystem allows the central government to mobilize any of these models to achieve its \npolicy intentions, whether written or unwritten; and \nd) the classical arguments of decentralization, particularly within a devolved system of \nco-operative governance where greater autonomy and authority are given to subnational \ngovernments, are found wanting within the South African governance \nsystem, given both the policy-making and fiscal resource strength of the central \ngovernment relative to the provinces. \nThis dissertation leads me to conclude that the South African practice of co-operative \ngovernance in the health system is actually imposed co-ordination and that provinces \nare de facto administration outposts of central government policies, programmes and \nservice delivery responsibilities. Therefore in reality there is no autonomy and \nindependence of the provinces from the central government as envisaged in the \nConstitution of the Republic of South Africa. In fact, provinces only exist, in terms of their \nconstitutional competencies as far the central government allows it to exist given its \nplenipotentiary powers over both micro and macro matters affecting institutions, fiscus \nand social policies.
Decentralization and democratization in Bolivia and Ecuador occurred in the context of regional and global trends that shifted powers from central to local governments and expanded citizen participation in public decision making. These trends converged with the return to civilian-elected rule in Latin America in the late 1970s and accelerated and deepened over the next decade. Latin America in subsequent decades produced some of the most admired decentralization experiences (Eaton 2004: 36). Development professionals embraced the writings of political theorists extolling the ânormative, substantive and instrumental benefits of participationâ (Humphreys et al. 2006: 585â6). By the 1990s virtually all major development players â multilateral and bilateral donors and civil society groups â had embraced a preference for governance methods that facilitate the autonomous involvement of stakeholders in the choice, design, implementation, and monitoring of development programs. Thus, when Andean indigenous governments sought new ways to link social-movement organizations with public decision-making bodies in the 1990s, they received enthusiastic support from many development actors. Before we investigate the variations in institutional innovation in particular municipalities, it is important to understand the enormous impact of the larger legal, political, and economic contexts in each country. We must remember that the most important decisions that affect local living conditions are made in distant national, and even international, capitols (Bebbington 2005: 5; Grindle 2007: 182â3). In the first section I describe the development of decentralization in Ecuador and Bolivia.
Based on the concept of autonomous cooperating holons, this paper presents a holonic command and control (C2) organizational control architecture (OCA) that models aC2organization as an integration of holonic multilevel decentralized decision-making networks. The OCA consists of two levels: operational- and tactical-level controls. Authority and control are highly distributed among agents belonging to different levels of the holarchy to empower the edges, whereas the integration of decisions is ensured to achieve overall mission objectives. In order to complete a mission in real time in dynamic environments, the decision makers (DMs) at different control levels need to coordinate their actions extensively and be prepared to adapt their schedules. Based on the proposed OCA, we present a holonic multiobjective evolutionary algorithm that produces flexible distributed schedules that account for the unexpected changes in the mission environment, such as asset breakdown, appearance of new events, DM failure, etc. This approach generates multilevel Pareto optimal solutions and, as a consequence, produces a set of ranked neighboring schedules. The actual schedule is a combination of different phases from alternative neighboring schedules that adapt to environmental disturbances. Moreover, the cost of adaptability is reduced while maintaining the stability of the organization. Numerical experiment shows the advantages of the proposed OCA, viz., simplicity, efficiency, and flexibility, which enable an organization to achieve high performance under dynamic and uncertain environments.
Systems Engineering Methodologies and Applications
Various types of probabilistic proof systems have played a central role in the development of computer science in the last couple of decades. These proof systems deviate from the traditional concept of a proof by introducing randomization and interaction into the verification process. Probabilistic proof systems carry an error probability (which is explicitly bounded and can be decreased by repetitions), but they offer various advantages over deterministic proof systems. This primer concentrates on three types of probabilistic proof systems: interactive proofs, zero-knowledge proofs, and Probabilistically Checkable Proofs (PCP). Surveying the basic results regarding these proof systems, we stress the essential role of randomness in each of them.
Lu Li, Jinsong Han, Yunhao Liu, Lei Hu · 7 authors
Most of the current trust models in peer-to-peer (P2P) systems are identity based, which means that in order for one peer to trust another, it needs to know the other peer's identity. Hence, there exists an inherent tradeoff between trust and anonymity. To the best of our knowledge, there is currently no P2P protocol that provides complete mutual anonymity as well as authentication and trust management. We propose a zero-knowledge authentication scheme called pseudo trust (PT), where each peer, instead of using its real identity, generates an unforgeable and verifiable pseudonym using a one-way hash function. A novel authentication scheme based on zero-knowledge proof is designed so that peers can be authenticated without leaking any sensitive information. With the help of PT, most existing identity-based trust management schemes become applicable in mutual anonymous P2P systems. We analyze the security and the anonymity in PT, and evaluate its performance using trace-driven simulations and a prototype PT-enabled P2P network. The strengths of our design include (1) no need for a centralized trusted party or CA, (2) high scalability and security, (3) low traffic and cryptography processing overheads, and (4) man-in-middle attack resistance.
On January 8, 1997, the former President of Brazil, Fernando Enrique Cardoso signed the National Water Resource Policy into law (Law No. 9.433, 1997). The key principles of the National Water Policy include: an integrated approach with the river basin as the planning unit, water as a fragile and finite resource, water as an economic good, and finally, decentralized and participatory management of the resource (Formiga and Scatasta, forthcoming). The legislation provided for the implementation of bulk water pricing with the resulting revenues meant to finance the activities mandated by basin committees in the watershed area of Rio ParaĂba Do Sul (in Rio de Janeiro and SĂŁo Paulo, and also in the state of Minas Gerais, that basin committee is ComitĂȘ para IntegraÏĂŁo da Bacia HidrogrĂĄfica do Rio ParaĂba Do Sul (CEIVAP) (Abers and Keck, 2004). To improve the sustainability of many different resources it is a widely accepted concept that charging a fee for something will spur sparing use by the target audience, particularly if the price is high. One-hundred percent of the collected monies have been invested within the basin; mainly designated to the following: non-structural institutional interventions, sediment control projects, and municipal wastewater treatment. Payments from agriculture and small hydroelectric plants have been mostly symbolic or non-existent and payments from other sectors have not been high enough to maintain a sustainable system. Convincing those that have not been actively participating is central to the success of this initiative: this paper will explain a framework called Social Marketing which is becoming more widely used throughout the globe to inspire behavior change. Social Marketing is a tool that can be used to persuade more users to pay the cobrança.
Open access
Water resources management and optimization
Conservation, Biodiversity, and Resource Management
Pursuant to the Local Self-Government Act adopted in February 2002, the fiscal decentralization has been carried out without the institutional decentralization of functions of the central tax administration, whereby only the affirmation of the self-government authorities has been done in the part of financing the budges of self-government units, but not in the part of administering the original local public revenues. The Local Self-Government Financing Act created a legal ground for decentralization of functions of the central tax administration (Tax Administration). Further concretization of competence of the local tax administration shall be done by the Amendment Act to the Tax procedure and Tax Administration Act.
A practical publicly verifiable secret sharing (PVSS) is constructed based on the bilinear pairing on elliptic curves, which has all advantages of B. Schoenmakerspsila PVSS and its secret is not the form of discrete logarithm, thus this PVSS is extremely practical. Moreover, in the schemepsilas distribution of shares phase, only using bilinearity of bilinear pairing, anybody can verify whether the participants received correct shares without implementing zero-knowledge proofs, without implementing the non-interactive protocol and without construction so called witness of shares applying Fiat-Shamirpsilas technique. Subsequently, in the schemepsilas reconstruction of secret phase, the released shares may be verified by anybody with the same method. Since the PVSS need not to implement non-interactive protocol to prevent malicious players. Therefore this scheme is simpler, more efficient and practical suitable for some especially case.