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Abdallah Almahmoud, Harendra S. Parekh, Brett M. Paterson, Karnaker R. Tupally · 8 authors
No abstract is available for this record.
Ayitila Maimaitijiang, Dongze He, Dingyang Li, Wenfang Li · 7 authors
Chemotherapy has been widely applied in oncotherapy. However, the development of multidrug resistance (MDR) has diminished the effectiveness of anticancer drugs against tumor cells. Such resistance often results in tumor recurrence, metastasis, and patient death. Fortunately, nanoparticle-based drug delivery systems provide a promising strategy by codelivery of multiple drugs and MDR reversal agents and the skillful, flexible, smart modification of drug targets. Such systems have demonstrated the ability to bypass the ABC transporter biological efflux mechanisms due to drug resistance. Hence, how to deliver drugs and exert potential antitumor effects have been successfully explored, applied, and developed. Furthermore, to overcome multidrug resistance, nanoparticle-based systems have been developed due to their good therapeutic effect, low side effects, and high tumor metastasis inhibition. In view of this, we systematically discuss the molecular mechanisms and therapeutic strategies of MDR from nanotherapeutics. Finally, we summarize intriguing ideas and future trends for further research in overcoming MDR.
Qiqian Liu, Fatima Aouidat, Pasquale Sacco, Eleonora Marsich · 6 authors
No abstract is available for this record.
Igor Galaev, Bo Mattiasson
Intelligent or smart polymers are biocompatible polymeric materials that can respond to the physiological or biological environment by expanding or contracting at different rates. This type of response can be used either to construct biomedical devices or to produce advanced responsive medical systems. In the pharmaceutical field, such systems have been used to develop new types of responsive or pulsatile delivery devices.