Blockchain Papers

Stanley Cho, Bomi Woo, Sung-Ung Kang

DNA-encoded chemical libraries (DECLs/DELs) enable the pooled synthesis and selection of millions to billions of DNA-barcoded small molecules, providing an efficient route to discover binders and early leads against diverse biological targets. As DEL-derived programs advance toward identifying clinical candidates, the asset surface of a DEL platform expands from a small set of optimized hits to include library designs, building-block combinations, DNA tags, selection data, and physical library stocks, thus creating new challenges in registration, traceability, and scalable ownership in transfer practices. Non-fungible tokens (NFTs) are unique blockchain-native tokens that can represent digital assets that can be coupled to smart contracts to enable traceable transactions and programmable rights management, which inspire proposals to tokenize intellectual-property (IP) assets such as patents. Here, we review (i) the scientific and commercial value of DEL in modern drug discovery, (ii) NFT/blockchain concepts, specifically in reported biomedical-IP and supply-chain use cases, and (iii) a conceptual architecture for NFT-enabled registration and controlled transfer of DEL libraries or sublibraries using on-chain identifiers with off-chain encrypted metadata and legal agreements.

Stephan Dübler, Federico Badaloni, Pedro Moreno-Sánchez, Clara Schneidewind

The heterogeneity of the blockchain landscape has motivated the design of blockchain protocols tailored to specific blockchains and applications that, hence, require custom security proofs. We observe that many blockchain protocols share common security and functionality goals, which can be captured by an atomic transfer graph (ATG) describing the structure of desired transfers. Based on this observation, we contribute a framework for generating secure-by-design protocols that realize these goals. The resulting protocols build upon Conditional Timelock Contracts (CTLCs), a novel minimal smart contract functionality that can be implemented in a large variety of cryptocurrencies with a restricted scripting language (e.g., Bitcoin), and payment channels. We show how ATGs, in addition to enabling novel applications, capture the security and functionality goals of existing applications, including many examples from payment channel networks and complex multi-party cross-currency swaps among Ethereum-style cryptocurrencies. Our framework is the first to provide generic and provably secure protocols for all these use cases while matching or improving the performance of existing use-case-specific protocols.

Farhana Javed, Josep Mangues‐Bafalluy

This paper presents a multi-contract blockchain framework for inter-provider agreements in 6G networks, emphasizing performance analysis under a realistic Proof-of-Stake (PoS) setting on Ethereum's Sepolia testnet. We begin by quantifying Ethereum Virtual Machine (EVM)-based gas usage for critical operations such as provider registration, service addition, and SLA penalty enforcement, observing that cold writes and deep data structures can each inflate gas consumption by up to 20\%. We then examine block-level dynamics when multiple transactions execute concurrently, revealing that moderate concurrency (e.g., 30--50 simultaneous transactions) can fill blocks to 80--90\% of their gas limit and nearly double finalization times from around 15~seconds to over 30~seconds. Finally, we synthesize these insights into a practical design guide, demonstrating that flattening nested mappings, consolidating storage writes, and selectively timing high-impact transactions can markedly reduce costs and latency spikes. Collectively, our findings underscore the importance of EVM-specific optimizations and transaction scheduling for large-scale decentralized applications in 6G telecom scenarios. The implementation is available online.

Viktor Valaštín, Dušan Morháč, Kristián Košťál, Ivan Kotuliak

Liquidity is critical for a healthy and thriving blockchain ecosystem, enabling value exchange between participants. However, achieving unified liquidity across heterogeneous blockchain platforms remains challenging due to disparities in architecture, virtual machines, and asset management logic. These disparities force assets to be wrapped into other formats to ensure compatibility with underlying systems, thus fragmenting liquidity into multiple pools. This paper proposes LiquiSpell, a novel protocol that aims to unify liquidity across multiple parachains within the Polkadot ecosystem. By leveraging the cross-chain message passing (XCMP), LiquiSpell introduces the concept of a universal transaction that can be constructed to be compatible with any parachain, regardless of its underlying architecture or asset management pallet. This approach overcomes the obstacles posed by the diverse nature of parachains, enabling seamless asset sharing and enhancing cross-chain interoperability. The proposed solution mitigates liquidity fragmentation within the Polkadot ecosystem. It presents a framework that can be extended to other multichain environments outside Polkadot. Ultimately, LiquiSpell aims to foster a thriving ecosystem by facilitating the introduction of new assets and increasing overall liquidity, thereby driving innovation and adoption within the decentralized finance (DeFi) landscape.

Shaoyuan Yu, Jing Yang, Jia Ni, Chun‐Yi Chen · 10 authors

Green and low-carbon development is an important part of global sustainable development. Green power trading provides strong support and assurance for promoting green and low-carbon development. Due to the long cycle of green power data chains and their susceptibility to malicious tampering, the integrity and traceability of data are difficult to guarantee. Therefore, this paper first proposes a security provenance model with enhanced relations based on the core structure of PROV and blockchain technology, which can securely capture provenance records, use the transfer time and number of transactions between various links in the traceability network as reasoning clues, realize the correlation tracing of the green electricity transfer process. Under the model, a traceability mechanism of green electricity is designed based on smart contracts. Trustworthy green electricity data collection is achieved through data filling and data verification techniques. Traceability query technique is adopted to achieve trustworthy traceability of green electricity. And the effectiveness of the proposed solution is demonstrated through simulation experiments.

Ray Neiheiser, Arman Babaei, Giannis Alexopoulos, Marios Kogias · 5 authors

Blockchain performance has historically faced challenges posed by the throughput limitations of consensus algorithms. Recent breakthroughs in research have successfully alleviated these constraints by introducing a modular architecture that decouples consensus from execution. The move toward independent optimization of the consensus layer has shifted attention to the execution layer. While concurrent transaction execution is a promising solution for increasing throughput, practical challenges persist. Its effectiveness varies based on the workloads, and the associated increased hardware requirements raise concerns about undesirable centralization. This increased requirement results in full nodes and stragglers synchronizing from signed checkpoints, decreasing the trustless nature of blockchain systems. In response to these challenges, this paper introduces Chiron, a system designed to extract execution hints for the acceleration of straggling and full nodes. Notably, Chiron achieves this without compromising the security of the system or introducing overhead on the critical path of consensus. Evaluation results demonstrate a notable speedup of up to 30%, effectively addressing the gap between theoretical research and practical deployment. The quantification of this speedup is achieved through realistic blockchain benchmarks derived from a comprehensive analysis of Ethereum and Solana workloads, constituting an independent contribution.

Rahul Konapure, Shankar Nawale

This paper introduces a cutting-edge smart logistics solution for Pharma Supply Chain Management (PSCM) by integrating smart contracts, logistics planning, and asset condition monitoring using Internet of Things (IoT) devices. Focused on enhancing accountability, traceability, and liability across the entire supply chain, the proposed model demonstrates realtime visibility as products move from the drug’s manufacturer to patients. In the PSCM, a critical concern is the safe and efficient delivery of medicines, particularly in maintaining precise temperature conditions. Addressing this challenge, the solution integrates blockchain, smart contracts, IoT sensors, and gas-efficient implementations. The system employs Radio Frequency (RF) sensors to collect accurately timestamped data, ensuring transparency and reliability in drug movement. Gas-efficient smart contracts streamline processes, revolutionizing pharmaceutical supply chain management and improving patient outcomes through real-time IoT monitoring, countering counterfeit drugs, and ensuring data integrity.

Sarmistha Sarna Gomasta, Aditi Dhali, Tahlil Tahlil, Md Musfique Anwar · 5 authors

Over the last decade, pharmaceutical businesses have battled to standardize product traceability across the supply chain process, enabling counterfeiters to enter the market with counterfeit pharmaceuticals. As a result, an end-to-end product tracking system is crucial for ensuring product safety and eliminating counterfeit products across the pharmaceutical supply chain. In this paper, we introduce PharmaChain, a decentralized hyperledger fabric framework that leverages confidentiality, accountability, and interoperability. This system enables on-chain and off-chain storage for secured, rapid transactions, along with smart contracts establishing data provenance. To demonstrate security, we have provided double signing through the elliptic curve digital signature algorithm, hash data encryption, and 33% node attack. The purpose of this suggested framework is to engage particular governance disciplines to assess its effectiveness in improving drug traceability across the pharmaceutical supply chain to preserve public health by preventing counterfeit pharmaceuticals.

Shannan Liu, Ronghua Zhang, Changzheng Liu, Du Shi

To solve the problems of high latency, high system overhead, and small supported scale in the current application of pharmaceutical traceability combined with blockchain technology, an algorithm called Pharmaceutical-Practical Byzantine Fault Tolerance (P-PBFT) based on PBFT, grouping, and credit voting is proposed. The algorithm combines the characteristics of a pharmaceutical supply chain, optimizes the consistency protocol in the original algorithm, divides large-scale network nodes into different consensus sets by response speed, and performs grouping consensus. The algorithm's credit model and voting mechanism dynamically updates user status according to the behavior of nodes in consensus, evaluates the reliability of users, and also serves as a basis for electing management nodes. Experimental results show that the improved P-PBFT consensus algorithm provides smaller latency and higher throughput for pharmaceutical traceability systems, supports larger-scale traceability, effectively alleviates the dramatic increase in communication among network nodes, and reduces the influence of malicious nodes.

Mariem Turki, Saoussen Cheikhrouhou, Bouthaina Dammak, Mouna Baklouti · 6 authors

The public’s health depends on a reliable drug supply chain. Recently, the number of drug counterfeit has increased drastically, resulting in thousands of victims suffering from poisoning and/or treatment failures, which have resulted in new expectations on drug supply chain traceability. Indeed, the drug supply chain involves many parties having heterogeneous interests and are usually reluctant to share traceability data with each other. Furthermore, existing traceability and provenance systems for drug supply chains suffer from separated data storage, lack of information sharing transparency, and trust. Decentralized blockchain-based solutions are advocated to address these limitations by realizing decentralized trustless systems. In this work, we present a fully decentralized, blockchain-based drug traceability solution, worthy of seamless integrating IoT devices throughout the chain. It uses both smart contracts and decentralized off-chain storage to remove the need for middleman and to provide trusted, secure and immutable transaction history. Moreover, to preserve the traceability of drugs, it ensures and enforces data provenance and data integrity in the proposed IoT environment by using blockchain Non-Fungible Tokens (NFTs). We give a test and validation of the approach’s effectiveness in enhancing drug traceability supply chains, as well as an analysis of the approach’s costs and security.

Magnus W. D. Hanson‐Heine, Alexander P. Ashmore

Abstract Simulations of molecules have recently been performed directly on a blockchain virtual computer at atomic resolution. This tutorial review covers the current applications of blockchain technology for molecular modeling in physics, chemistry, and biology, and provides a step‐by‐step tutorial for computational scientists looking to use blockchain computers to simulate physical and scientific processes in general. Simulations of carbon monoxide have been carried out using molecular dynamics software on the Ethereum blockchain in order to facilitate the tutorial.

Raiane Coelho, Regina Braga, José David, Victor Ströele · 6 authors

No abstract is available for this record.

Michael Sammeth, Nicu-Cosmin Ursache, Sînică Alboaie

Introduction: Distributed ledger networks, chiefly those based on blockchain technologies, currently are heralding a next-generation of computer systems that aims to suit modern users’ demands. Over the recent years, several technologies for blockchains, off-chaining strategies, as well as decentralised and respectively self-sovereign identity systems have shot up so fast that standardisation of the protocols is lagging behind, severely hampering the interoperability of different approaches. Moreover, most of the currently available solutions for distributed ledgers focus on either home users or enterprise use case scenarios, failing to provide integrative solutions addressing the needs of both. Methods: Herein, we introduce the OpenDSU platform that allows to interoperate generic blockchain technologies, organised–and possibly cascaded in a hierarchical fashion–in domains. To achieve this flexibility, we seamlessly integrated a set of well conceived components that orchestrate off-chain data and provide granularly resolved and cryptographically secure access levels, intrinsically nested with sovereign identities across the different domains. The source code and extensive documentation of all OpenDSU components described herein are publicly available under the MIT open-source licence at https://opendsu.com . Results: Employing our platform to PharmaLedger, an inter-European network for the standardisation of data handling in the pharmaceutical industry and in healthcare, we demonstrate that OpenDSU can cope with generic demands of heterogeneous use cases in both, performance and handling substantially different business policies. Discussion: Importantly, whereas available solutions commonly require a pre-defined and fixed set of components, no such vendor lock-in restrictions on the blockchain technology or identity system exist in OpenDSU, making systems built on it flexibly adaptable to new standards evolving in the future.

Élton Carneiro Marinho, Éber Assis Schmitz, Sérgio Manuel Serra da Cruz

Blockchain technology combined with Data provenance is one way to make soil data more trustworthy and traceable by providing tamper-proof information about the origin, transformations, and history of pieces of data. We present Hyperledger Fabric of FAIRCHAIN, a computational infrastructure that manages smart contracts that uses soil data. We aim to mitigate the open challenges of the agricultural food supply chain, specifically in the difficulty of traceability of soil data. In this work, we present the mechanism to structure a smart contract using soil data enriched with retrospective provenance metadata. The infrastructure can hold workflow implementations.

Faisal Albalwy, John McDermott, William G. Newman, Andy Brass · 5 authors

The successful implementation of pharmacogenetics (PGx) into clinical practice requires patient genomic data to be shared between stakeholders in multiple settings. This creates a number of barriers to widespread adoption of PGx, including privacy concerns related to the storage and movement of identifiable genomic data. Informatic solutions that support secure and equitable data access for genomic data are therefore important to PGx. Here we propose a methodology that uses smart contracts implemented on a blockchain-based framework, PGxChain, to address this issue. The design requirements for PGxChain were identified through a systematic literature review, identifying technical challenges and barriers impeding the clinical implementation of pharmacogenomics. These requirements included security and privacy, accessibility, interoperability, traceability and legal compliance. A proof-of-concept implementation based on Ethereum was then developed that met the design requirements. PGxChain's performance was examined using Hyperledger Caliper for latency, throughput, and transaction success rate. The findings clearly indicate that blockchain technology offers considerable potential to advance pharmacogenetic data sharing, particularly with regard to PGx data security and privacy, large-scale accessibility of PGx data, PGx data interoperability between multiple health care providers and compliance with data-sharing laws and regulations.

Hayes Kathleen

Substandard and falsified (SF) pharmaceuticals account for an estimated 10% of the pharmaceutical supply chain in low- and middle-income countries (LMICs), where a lack of regulatory and laboratory resources limits the ability to conduct effective post-market surveillance and allows SF products to penetrate the supply chain. The Distributed Pharmaceutical Analysis Laboratory (DPAL) was established in 2014 to expand testing of pharmaceutical dosage forms sourced from LMICs; DPAL is an alliance of academic institutions throughout the United States and abroad that provides high quality, validated chemical analysis of pharmaceutical dosage forms sourced from partners in LMICs. Results from analysis are reported to relevant regulatory agencies and are used to inform purchasing decisions made by in-country stakeholders. As the DPAL program has expanded to testing more than 1000 pharmaceutical dosage forms annually, challenges have surfaced regarding data management and sample tracking. Here, we describe a pilot project between DPAL and ARTiFACTs that applies blockchain to organize and manage key data generated during the DPAL workflow, including a sample’s progress through the workflow, its physical location, provenance of metadata, and lab reputability. Recording time and date stamps with this data will create a permanent and verifiable chain-of-custody for samples. This secure, distributed ledger will be linked to an easy-to-use dashboard, allowing stakeholders to view results and experimental details for each sample in real time and verify the integrity of DPAL analysis data. Introducing this blockchain-based system as a pilot will allow us to test the technology with real users analyzing real samples. Feedback from users will be recorded and necessary adjustments will be made to the system before the implementation of blockchain across all DPAL sites. Anticipated benefits of implementing blockchain for managing DPAL data include efficient management for routing work, increasing throughput, creating a chain of custody for samples and their data in alignment with the distributed nature of DPAL, and using the analysis results to detect patterns of quality within and across brands of products and develop enhanced sampling techniques and best practices. 

Kathleen L. Hayes, Natalie Meyers, Christopher Sweet, Ayenew Ashenef · 7 authors

Substandard and falsified (SF) pharmaceuticals account for an estimated 10% of the pharmaceutical supply chain in low- and middle-income countries (LMICs), where a lack of regulatory and laboratory resources limits the ability to conduct effective post-market surveillance and allows SF products to penetrate the supply chain. The Distributed Pharmaceutical Analysis Laboratory (DPAL) was established in 2014 to expand testing of pharmaceutical dosage forms sourced from LMICs; DPAL is an alliance of academic institutions throughout the United States and abroad that provides high-quality, validated chemical analysis of pharmaceutical dosage forms sourced from partners in LMICs. Results from analysis are reported to relevant regulatory agencies and are used to inform purchasing decisions made by in-country stakeholders. As the DPAL program has expanded to testing more than 1,000 pharmaceutical dosage forms annually, challenges have surfaced regarding data management and sample tracking. Here, we describe a pilot project between DPAL and ARTiFACTs that applies the blockchain to organize and manage key data generated during the DPAL workflow, including a sample's progress through the workflow, its physical location, provenance of metadata, and lab reputability. Recording time and date stamps with these data will create a permanent and verifiable chain of custody for samples. This secure, distributed ledger will be linked to an easy-to-use dashboard, allowing stakeholders to view results and experimental details for each sample in real time and verify the integrity of DPAL analysis data. Introducing this blockchain-based system as a pilot will allow us to test the technology with real users analyzing real samples. Feedback from users will be recorded and necessary adjustments will be made to the system before the implementation of blockchain across all DPAL sites. Anticipated benefits of implementing the blockchain technology for managing DPAL data include efficient management for routing work, increasing throughput, creating a chain of custody for samples and their data in alignment with the distributed nature of DPAL, and using the analysis results to detect patterns of quality within and across brands of products and develop enhanced sampling techniques and best practices.

Jens Ducrée

Since its inception in the late 2000s, blockchain has emerged as a powerful tool for creating trust without intermediaries to incentivize global communities for working for a common goal, such as the improvement of its very ecosystem, its applications and community adoption. While first blockchains were mainly devised for confirming transactions of their innate cryptocurrencies like Bitcoin, smart-contract blockchains like Ethereum can interface with the real-world through so-called “oracles”, which feed trustful off-chain information. This paper introduces digital twins of physical objects and processes as computational oracles to effectively unleash the tremendous opportunity offered by blockchain to the realm of fundamental science, research and technology development (RTD). The crowdsourcing concept is illustrated with the example of centrifugal flow control in microfluidic “Lab-on-a-Disc” (LoaD) systems.

Mueen Uddin, Khaled Salah, Raja Jayaraman, Saša Pešić · 5 authors

Pharmaceutical supply chain (PSC) consists of multiple stakeholders including raw material suppliers, manufacturers, distributors, regulatory authorities, pharmacies, hospitals, and patients. The complexity of product and transaction flows in PSC requires an effective traceability system to determine the current and all previous product ownerships. In addition, digitizing track and trace process provides significant benefit for regulatory oversight and ensures product safety. Blockchain-based drug traceability offers a potential solution to create a distributed shared data platform for an immutable, trustworthy, accountable and transparent system in the PSC. In this paper, we present an overview of product traceability issues in the PSC and envisage how blockchain technology can provide effective provenance, track and trace solution to mitigate counterfeit medications. We propose two potential blockchain based decentralized architectures, Hyperledger Fabric and Besu to meet critical requirements for drug traceability such as privacy, trust, transparency, security, authorization and authentication, and scalability. We propose, discuss, and compare two potential blockchain architectures for drug traceability. We identify and discuss several open research challenges related to the application of blockchain technology for drug traceability. The proposed blockchain architectures provide a valuable roadmap for Health Informatics researchers to build and deploy an end-to-end solution for the pharmaceutical industry.

Mohammad Madine, Khaled Salah, Raja Jayaraman, Yousof Al-Hammadi · 6 authors

Blockchain technology has the potential to revolutionize industries by offering decentralized, transparent, data provenance, auditable, reliable, and trustworthy features. However, cross-chain interoperability is one of the crucial challenges preventing widespread adoption of blockchain applications. Cross-chain interoperability represents the ability for one blockchain network to interact and share data with another blockchain network. Contemporary cross-chain interoperability solutions are centralized and require re-engineering of the core blockchain stack to enable inter-communication and data sharing among heterogeneous blockchain networks. In this paper, we propose an application-based cross-chain interoperability solution that allows blockchain networks of any architecture type and industrial focus to inter-communicate, share data, and make requests. Our solution utilizes the decentralized applications as a distributed translation layer that is capable of communicating and understanding multiple blockchain networks, thereby delegating requests and parameters among them. The architecture uses incentivized verifier nodes that maintain the integrity of shared data facilitating them to be readable by the entities of their network. We define and describe the roles and requirements of major entities of inter-operating blockchain networks in the context of healthcare. We present a detailed explanation of the sequence of interactions needed to share an Electronic Medical Record (EMR) document from one blockchain network to another along with the required algorithms. We implement the proposed solution with Ethereum-based smart contracts for two hospitals and also present cost and security analysis for the cross-chain interoperability solution. We make our smart contracts code and testing scripts publicly available.

Boris Düdder, Vladislav V. Fomin, Tan Gürpinar, Michael Henke · 9 authors

The early development of blockchain technology (BCT) has already demonstrated the technology's potential to serve the needs of different industries. BCT has also become established as a popular research topic in different scientific disciplines. This paper aims at introducing how several relevant scientific disciplines—supply chain management; management, economics and finance; computer science; security engineering—see the research and education perspectives for BCT. A field review is conducted to present challenges and opportunities of BCT, as well as suggestions for future research and education on the topic as seen from the selected different perspectives. The paper also presents methods for combining relevant disciplines in a modular online course to address the stated challenges and promote interdisciplinary blockchain education.

Christoffer Olsson, Mohsen Toorani

Research and development of novel molecular compounds in the pharmaceutical industry can be highly costly. Lack of confidentiality can prevent a product from being patented or commercialized. As an effect, cross-organizational collaboration is virtually non-existent. In this paper, we introduce a blockchain-based solution to the collaborative drug discovery problem so that participants can maintain full ownership of the asset and upload partial information about molecules without revealing the molecule itself. A prototype is also implemented using the blockchain technology Hyperledger Fabric and analyzed from security and performance perspectives. The prototype provides a set of functionalities that makes sure that ownership is maintained, integrity is protected, and critical information remains confidential. From a performance perspective, it provides a good throughput and latency in the order of milliseconds. However, further improvements could be done to the scalability of the syst em.

Ahmad Musamih, Raja Jayaraman, Khaled Salah, Haya R. Hasan · 6 authors

Distribution and delivery of Coronavirus 2019 (COVID-19) vaccines have become challenging after their emergence. Today's platforms and systems leveraged for managing data related to COVID-19 vaccines' distribution and delivery fall short in providing transparency, trackability and traceability, immutability, audit, and trust features. Also, they are vulnerable to the single point of failure problem due to centralization. Such limitations hindering the safe, secure, transparent, trustworthy, and reliable distribution and delivery process of COVID-19 vaccines. In this paper, we propose an Ethereum blockchain-based solution for managing data related to COVID-19 vaccines' distribution and delivery. We develop smart contracts to automate the traceability of COVID-19 vaccines while ensuring data provenance, transparency, security, and accountability. We integrate the Ethereum blockchain with off-chain storage to manage non-critical and large-sized data. We present algorithms and discuss their full implementation, testing, and validation details. We evaluate the proposed solution by performing cost and security analysis as well as comparing it with the existing non-blockchain and blockchain-based solutions. Performance evaluation results reveal that the proposed solution is low-cost, and our smart contracts are secure enough against possible attacks and vulnerabilities. The smart contracts code along with testing scripts is made publicly available.

David F. Ferraiolo, Joanna F. DeFranco, D. Richard Kuhn, Joshua Roberts

Distributed systems have always presented complex challenges, and technology trends are in many ways making the software designer's job more difficult. In particular, today's systems must successfully handle.