Blockchain Papers

Sai Batchu, Owen S. Henry, Karan Patel, Abraham Hakim · 7 authors

No abstract is available for this record.

Alberto Tagliafico, Cristina Campi, Bianca Bignotti, Chandra Bortolotto · 9 authors

Blockchain usage in healthcare, in radiology, in particular, is at its very early infancy. Only a few research applications have been tested, however, blockchain technology is widely known outside healthcare and widely adopted, especially in Finance, since 2009 at least. Learning by history, radiology is a potential ideal scenario to apply this technology. Blockchain could have the potential to increase radiological data value in both clinical and research settings for the patient digital record, radiological reports, privacy control, quantitative image analysis, cybersecurity, radiomics and artificial intelligence.Up-to-date experiences using blockchain in radiology are still limited, but radiologists should be aware of the emergence of this technology and follow its next developments. We present here the potentials of some applications of blockchain in radiology.

Francesco Maria Carrano, Pierpaolo Sileri, Susie Batt, Nicola Di Lorenzo

No abstract is available for this record.

Zixiong Zhao, Jiaqi Ma

With the increasing number of coronavirus disease 2019 cases and worldwide vaccination coverage, 'vaccination passports' (vaccination certificates) may become a required permit for global travel, thereby supporting economic recovery. On March 7, 2021, Wang Yi, State Councilor and Foreign Minister of China, announced the launch of the Chinese version of an 'international travel health certificate' at a press conference of the National People's Congress and the Chinese Political Consultative Conference. He proposed a feasible 'Chinese solution' for promoting the recovery of the global economy and the facilitation of cross-border travel, and hoped that the international travel health certificate and vaccination passport can be mutually authenticated. The Israeli government issued a

Alaa Haddad, Mohamed Hadi Habaebi, Md. Rafiqul Islam, Nurul Fadzlin Hasbullah · 5 authors

Electronic health records (EHRs) are digitally saved health records that provide information about a person’s health. EHRs are generally shared among healthcare stakeholders, and thus are susceptible to power failures, data misuse, a lack of privacy, security, and an audit trail, among other problems. Blockchain, on the other hand, is a groundbreaking technology that provides a distributed and decentralized environment in which nodes in a list of networks can connect to each other without the need for a central authority. It has the potential to overcome the limits of EHR management and create a more secure, decentralized, and safer environment for exchanging EHR data. Further, blockchain is a distributed ledger on which data can be stored and shared in a cryptographically secure, validated, and mutually agreed-upon manner across all mining nodes. The blockchain stores data with a high level of integrity and robustness, and it cannot be altered. When smart contracts are used to make decisions and conduct analytics with machine-learning algorithms, the results may be trusted and unquestioned. However, Blockchain is not always indestructible and suffers from scalability and complexity issues that might render it inefficient. Combining AI and blockchain technology can handled some of the drawbacks of these two technical ecosystems effectively. AI algorithms rely on data or information to learn, analyze, and reach conclusions. The performance of AI algorithms is enhanced through the data obtained from a data repository or a reliable, secure, trustworthy, and credible platform. Researchers have identified three categories of blockchain-based potential solutions for the management of electronic health records: conceptual, prototype, and implemented. The purpose of this research work is to conduct a Systematic Literature Review (SLR) to identify and assess research articles that were either conceptual or implemented to manage EHRs using blockchain technology. The study conducts a comprehensive evaluation of the literature on blockchain technology and enhanced health record management systems utilizing artificial intelligence technologies. The study examined 189 research papers collected from various publication categories. The in-depth analysis focuses on the privacy, security, accessibility, and scalability of publications. The SLR has illustrated that blockchain technology has the potential to deliver decentralization, security, and privacy that are frequently lacking in traditional EHRs. Additionally, the outcomes of the extensive analysis inform future researchers about the type of blockchain to use in their research. Additionally, methods used in healthcare are summarized per application area while their pros and cons are highlighted. Finally, the emphasized taxonomy combines blockchain and artificial intelligence, which enables us to analyze possible blockchain and artificial intelligence applications in health records management systems. The article ends with a discussion on open issues for research and future directions.

Ioannis Karamitsos, Maria Papadaki

COVID-19 is a pandemic outbreak for each country worldwide. Each government needs to monitor every citizen and the COVID-19 test becomes an essential evidence for people who are travelling. This gives rise to the necessity of disruptive technologies such as Blockchain. In this paper, we provide an overview of the Hyperledger and Ethereum platforms and present how healthcare organizations can control and monitor digital health test certificates with citizens or other stakeholders. We also present a smart contract structure and implementation for COVID-19 test certificates in both blockchain platforms.

Andy S. K. Cheng, Qiongyao Guan, Yan Su, Ping Zhou · 5 authors

This brief report aimed to describe a narrative review about the application of machine learning (ML) methods and Blockchain technology (BCT) in the healthcare field, and to illustrate the integration of these two technologies in cancer survivorship care. A total of six eligible papers were included in the narrative review. ML and BCT are two data-driven technologies, and there is rapidly growing interest in integrating them for clinical data management and analysis in healthcare. The findings of this report indicate that both technologies can integrate feasibly and effectively. In conclusion, this brief report provided the state-of-art evidence about the integration of the most promising technologies of ML and BCT in health field, and gave an example of how to apply these two most disruptive technologies in cancer survivorship care.

Ruonan Wang, Min Luo, Yihong Wen, Lianhai Wang · 6 authors

There has been increased interest in applying artificial intelligence (AI) in various settings to inform decision-making and facilitate predictive analytics. In recent times, there have also been attempts to utilize blockchain (a peer-to-peer distributed system) to facilitate AI applications, for example, in secure data sharing (for model training), preserving data privacy, and supporting trusted AI decision and decentralized AI. Hence, in this paper, we perform a comprehensive review of how blockchain can benefit AI from these four aspects. Our analysis of 27 English-language articles published between 2018 and 2021 identifies a number of research challenges and opportunities.

Priti Tagde, Sandeep Tagde, Sandeep Tagde, Tanima Bhattacharya · 10 authors

Blockchain and artificial intelligence technologies are novel innovations in healthcare sector. Data on healthcare indices are collected from data published on Web of Sciences and other Google survey from various governing bodies. In this review, we focused on various aspects of blockchain and artificial intelligence and also discussed about integrating both technologies for making a significant difference in healthcare by promoting the implementation of a generalizable analytical technology that can be integrated into a more comprehensive risk management approach. This article has shown the various possibilities of creating reliable artificial intelligence models in e-Health using blockchain, which is an open network for the sharing and authorization of information. Healthcare professionals will have access to the blockchain to display the medical records of the patient, and AI uses a variety of proposed algorithms and decision-making capability, as well as large quantities of data. Thus, by integrating the latest advances of these technologies, the medical system will have improved service efficiency, reduced costs, and democratized healthcare. Blockchain enables the storage of cryptographic records, which AI needs.

Reyes-González Juan Pablo, Roberto Díaz-Peregrino, Victor SOTO-ULLOA, Isabel GALVAN-REMIGIO · 6 authors

In the last decades big data has facilitating and improving our daily duties in the medical research and clinical fields; the strategy to get to this point is understanding how to organize and analyze the data in order to accomplish the final goal that is improving healthcare system, in terms of cost and benefits, quality of life and outcome patient. The main objective of this review is to illustrate the state-of-art of big data in healthcare, its features and architecture. We also would like to demonstrate the different application and principal mechanisms of big data in the latest technologies known as blockchain and artificial intelligence, recognizing their benefits and limitations. Perhaps, medical education and digital anatomy are unexplored fields that might be profitable to investigate as we are proposing. The healthcare system can be revolutionized using these different technologies. Thus, we are explaining the basis of these systems focused to the medical arena in order to encourage medical doctors, nurses, biotechnologies and other healthcare professions to be involved and create a more efficient and efficacy system.

Sin Kit Lo, Yue Liu, Qinghua Lu, Chen Wang · 7 authors

Federated learning is an emerging privacy-preserving AI technique where clients (i.e., organisations or devices) train models locally and formulate a global model based on the local model updates without transferring local data externally. However, federated learning systems struggle to achieve trustworthiness and embody responsible AI principles. In particular, federated learning systems face accountability and fairness challenges due to multi-stakeholder involvement and heterogeneity in client data distribution. To enhance the accountability and fairness of federated learning systems, we present a blockchain-based trustworthy federated learning architecture. We first design a smart contract-based data-model provenance registry to enable accountability. Additionally, we propose a weighted fair data sampler algorithm to enhance fairness in training data. We evaluate the proposed approach using a COVID-19 X-ray detection use case. The evaluation results show that the approach is feasible to enable accountability and improve fairness. The proposed algorithm can achieve better performance than the default federated learning setting in terms of the model's generalisation and accuracy.

Mohamed Yaseen Jabarulla, Heung-No Lee

The world is facing multiple healthcare challenges because of the emergence of the COVID-19 (coronavirus) pandemic. The pandemic has exposed the limitations of handling public healthcare emergencies using existing digital healthcare technologies. Thus, the COVID-19 situation has forced research institutes and countries to rethink healthcare delivery solutions to ensure continuity of services while people stay at home and practice social distancing. Recently, several researchers have focused on disruptive technologies, such as blockchain and artificial intelligence (AI), to improve the digital healthcare workflow during COVID-19. Blockchain could combat pandemics by enabling decentralized healthcare data sharing, protecting users' privacy, providing data empowerment, and ensuring reliable data management during outbreak tracking. In addition, AI provides intelligent computer-aided solutions by analyzing a patient's medical images and symptoms caused by coronavirus for efficient treatments, future outbreak prediction, and drug manufacturing. Integrating both blockchain and AI could transform the existing healthcare ecosystem by democratizing and optimizing clinical workflows. In this article, we begin with an overview of digital healthcare services and problems that have arisen during the COVID-19 pandemic. Next, we conceptually propose a decentralized, patient-centric healthcare framework based on blockchain and AI to mitigate COVID-19 challenges. Then, we explore the significant applications of integrated blockchain and AI technologies to augment existing public healthcare strategies for tackling COVID-19. Finally, we highlight the challenges and implications for future research within a patient-centric paradigm.

Francesco Sanmarchi, F Toscano, M Fattorini, Andrea Bucci · 5 authors

Modern healthcare management and clinical practice strongly rely on data and scientific evidence. Digital technologies, tools, and services are core components of Healthcare Management and scientific Research (HMR). Data interoperability, security, privacy, and ease of sharing represent fundamental conditions for guaranteeing quality HMR. Current data management solutions in HMR are mainly built on two technological infrastructures: cloud-based (CB) or distributed ledger systems (DLTs). DLTs offer alternative and reliable alternatives for the management and sharing of data in HMR. Their use can help increase confidence and trust in the integrity of data and the resulting evidence. 
\nThe aim of this paper is to shed light on CB and DLT solutions, emphasizing the potential role of innovative digital solutions based on DLTs in creating a data-driven transformation of HMR, and to describe relevant examples and practical uses of DLT-based solutions for patients, healthcare management, and research activities. 
\nDLTs in particular can be increasingly useful for patients to truly have control over their health, for healthcare policymakers to increase the quality of organizational processes, and for research funders, editors and publishers to increase the return on investment, and the reuse and reproducibility of research. 
\nIn conclusion, harnessing the potential of digital technologies is essential to transform healthcare management and research, by enhancing data quality, reliability, and trust.

European Society of Radiology (ESR), Elmar Kotter, Luis Martí‐Bonmatí, Adrian P. Brady · 5 authors

Blockchain can be thought of as a distributed database allowing tracing of the origin of data, and who has manipulated a given data set in the past. Medical applications of blockchain technology are emerging. Blockchain has many potential applications in medical imaging, typically making use of the tracking of radiological or clinical data. Clinical applications of blockchain technology include the documentation of the contribution of different "authors" including AI algorithms to multipart reports, the documentation of the use of AI algorithms towards the diagnosis, the possibility to enhance the accessibility of relevant information in electronic medical records, and a better control of users over their personal health records. Applications of blockchain in research include a better traceability of image data within clinical trials, a better traceability of the contributions of image and annotation data for the training of AI algorithms, thus enhancing privacy and fairness, and potentially make imaging data for AI available in larger quantities. Blockchain also allows for dynamic consenting and has the potential to empower patients and giving them a better control who has accessed their health data. There are also many potential applications of blockchain technology for administrative purposes, like keeping track of learning achievements or the surveillance of medical devices. This article gives a brief introduction in the basic technology and terminology of blockchain technology and concentrates on the potential applications of blockchain in medical imaging.

Jan Witowski, Jongmum Choi, Soomin Jeon, Doyun Kim · 9 authors

Current research on medical image processing relies heavily on the amount and quality of input data. Specifically, supervised machine learning methods require well-annotated datasets. A lack of annotation tools limits the potential to achieve high-volume processing and scaled systems with a proper reward mechanism. We developed MarkIt, a web-based tool, for collaborative annotation of medical imaging data with artificial intelligence and blockchain technologies. Our platform handles both Digital Imaging and Communications in Medicine (DICOM) and non-DICOM images, and allows users to annotate them for classification and object detection tasks in an efficient manner. MarkIt can accelerate the annotation process and keep track of user activities to calculate a fair reward. A proof-of-concept experiment was conducted with three fellowship-trained radiologists, each of whom annotated 1,000 chest X-ray studies for multi-label classification. We calculated the inter-rater agreement and estimated the value of the dataset to distribute the reward for annotators using a crypto currency. We hypothesize that MarkIt allows the typically arduous annotation task to become more efficient. In addition, MarkIt can serve as a platform to evaluate the value of data and trade the annotation results in a more scalable manner in the future. The platform is publicly available for testing on https://markit.mgh.harvard.edu.

Daniel Cabrera, Christopher P Nickson, Damian Roland, Elissa Hall · 5 authors

UNSTRUCTURED Current health professions education (HPE) institutions are based on an assembly-line hierarchical structure. The last decade has witnessed the advent of sophisticated networks allowing the exchange of information and educational assets. Blockchain provides an ideal data management framework that can support high-order applications such as learning systems and credentialing in an open and a distributed fashion. These system management characteristics enable the creation of a distributed autonomous organization of learning (DAOL). This new type of organization allows for the creation of decentralized adaptive competency curricula, simplification of credentialing and certification, leveling of information asymmetry among educational market stakeholders, assuring alignment with societal priorities, and supporting equity and transparency.

Tim Joda, Nikolaos Pandis

No abstract is available for this record.

Anjum Khurshid, Cole Holan, Cody Cowley, Jeremiah Alexander · 9 authors

OBJECTIVE: Healthcare systems suffer from a lack of interoperability that creates "data silos," causing patient linkage and data sharing problems. Blockchain technology's unique architecture provides individuals greater control over their information and may help address some of the problems related to health data. A multidisciplinary team designed and tested a blockchain application, MediLinker, as a patient-centric identity management system. METHODS: The study used simulated data of "avatars" representing different types of patients. Thirty study participants were enrolled to visit simulated clinics, and perform various activities using MediLinker. Evaluation was based on Bouras' criteria for patient-centric identity management and on the number of errors in entry and sharing of data by participants. RESULTS: Twenty-nine of the 30 participants completed all study activities. MediLinker fulfilled all of Bouras' criteria except for one which was not testable. A majority of data errors were due to user error, such as wrong formatting and misspellings. Generally, the number of errors decreased with time. Due to COVID-19, sprint 2 was completed using "virtual" clinic visits. The number of user errors were less in virtual visits than in personal visits. DISCUSSION: The evaluation of MediLinker provides some evidence of the potential of a patient-centric identity management system using blockchain technology. The results showed a working system where patients have greater control over their information and can also easily provide consent for use of their data. CONCLUSION: Blockchain applications for identity management hold great promise for use in healthcare but further research is needed before real-world adoption.

Satyabrata Aich, Nday Kabulo Sinai, Saurabh Kumar, Mohammed Al Ali · 7 authors

For decades artificial intelligence (AI) has been used for various applications in the healthcare industry. Machine learning and artificial intelligence algorithms allow us to diagnose and customize medical care and follow-up plans to get better results, and during the covid19 pandemic, it was found that AI models have been using to predict the Covid-19 symptoms, understanding how it spreads, speeding up research and treatment using medical data. However, it is very challenging to make a robust AI model and use it in a real-time and real-world environment since most organizations do not want to share their data with other third parties due to privacy concerns, furthermore, it is difficult to build a generalized prediction model because of the fragmented nature of the patient data across the healthcare system. To solve the above problems, this paper presents a solution based on blockchain and AI technologies. The blockchain will securely protect the data access and AI-based federated learning for building a robust model for global and real-time usage.

Lamine Amour, Matthieu Quiniou, Sara Tucci-Piergiovanni, Hichem Bourak · 5 authors

No abstract is available for this record.

Raja Wasim Ahmad, Khaled Salah, Raja Jayaraman, Ibrar Yaqoob · 6 authors

<div><b>Objectives: </b>Telehealth and telemedicine systems aim to deliver remote healthcare services to mitigate the spread of COVID‐19. Also, they can help to manage scarce healthcare resources to control the massive burden of COVID-19 patients in hospitals. However, a large portion of today's telehealth and telemedicine systems are centralized and fall short of providing necessary information security and privacy, operational transparency, health records immutability, and traceability to detect frauds related to patients' insurance claims and physician credentials.</div><div><b>Methods: </b>The current study has explored the potential opportunities and adaptability challenges for blockchain technology in telehealth and telemedicine sector. It has explored the key role that blockchain technology can play to provide necessary information security and privacy, operational transparency, health records immutability, and traceability to detect frauds related to patients' insurance claims and physician credentials.</div><div><b>Results: </b>Blockchain technology can improve telehealth and telemedicine services by offering remote healthcare services in a manner that is decentralized, tamper-proof, transparent, traceable, reliable, trustful, and secure. It enables health professionals to accurately identify frauds related to physician educational credentials and medical testing kits commonly used for home-based diagnosis.</div><div><b>Conclusions: </b>Wide deployment of blockchain in telehealth and telemedicine technology is still in its infancy. Several challenges and research problems need to be resolved to enable the widespread adoption of blockchain technology in telehealth and telemedicine systems.</div><div> </div><div><br></div>

H. S. Jennath, V. S. Anoop, S. Asharaf

Advances in information technology are digitizing the healthcare domain with the aim of improved medical services, diagnostics, continuous monitoring using wearables, etc., at reduced costs. This digitization improves the ease of computation, storage and access of medical records which enables better treatment experiences for patients. However, it comes with a risk of cyber attacks and security and privacy concerns on this digital data. In this work, we propose a Blockchain based solution for healthcare records to address the security and privacy concerns which are currently not present in existing e-Health systems. This work also explores the potential of building trusted Artificial Intelligence models over Blockchain in e-Health, where a transparent platform for consent-based data sharing is designed. Provenance of the consent of individuals and traceability of data sources used for building and training the AI model is captured in an immutable distributed data store. The audit trail of the data access captured using Blockchain provides the data owner to understand the exposure of the data. It also helps the user to understand the revenue models that could be built on top of this framework for commercial data sharing to build trusted AI models.

Yunlong Lu, Xiaohong Huang, Ke Zhang, Sabita Maharjan · 5 authors

Emerging technologies, such as digital twins and 6th generation (6G) mobile networks, have accelerated the realization of edge intelligence in industrial Internet of Things (IIoT). The integration of digital twin and 6G bridges the physical system with digital space and enables robust instant wireless connectivity. With increasing concerns on data privacy, federated learning has been regarded as a promising solution for deploying distributed data processing and learning in wireless networks. However, unreliable communication channels, limited resources, and lack of trust among users hinder the effective application of federated learning in IIoT. In this article, we introduce the digital twin wireless networks (DTWN) by incorporating digital twins into wireless networks, to migrate real-time data processing and computation to the edge plane. Then, we propose a blockchain empowered federated learning framework running in the DTWN for collaborative computing, which improves the reliability and security of the system and enhances data privacy. Moreover, to balance the learning accuracy and time cost of the proposed scheme, we formulate an optimization problem for edge association by jointly considering digital twin association, training data batch size, and bandwidth allocation. We exploit multiagent reinforcement learning to find an optimal solution to the problem. Numerical results on real-world dataset show that the proposed scheme yields improved efficiency and reduced cost compared to benchmark learning methods.

Ilhaam A. Omar, Raja Jayaraman, Khaled Salah, Ibrar Yaqoob · 5 authors

Blockchain technology has disclosed unprecedented opportunities in the healthcare sector by unlocking the true value of interoperability. Specifically, the striking features of blockchain technology, such as data provenance, transparency, decentralized transaction validation, and immutability can help to compensate for stringent data management issues (e.g., patient recruitment, persistent monitoring, data management, and data analytics and accurate reporting) in clinical trials (CTs). Although several research studies show that blockchain solutions help to improve patient retention, data integrity, privacy, and ensure CTs compliance with regulatory policies, a comprehensive survey on this topic is lacking. In this survey, we provide insights into the adoption of blockchain technology in CTs. We categorize and classify the literature by devising a meticulous taxonomy of the decentralized tasks of CT and practices based on indispensable parameters. Furthermore, we provide insights on works in progress towards deploying blockchain solutions in CTs. Finally, we identify and discuss several challenges that hinder the successful implementation of blockchain technologies in CTs.