A Secure Blockchain Framework for Smart Property Ownership Verification Using Smart Contracts

Abstract

Progesterone is a vital endogenous steroid hormone extensively used in hormone replacement therapy, contraception, infertility management, and various gynaecological disorders. Despite its significant therapeutic importance, its clinical effectiveness is severely limited by poor aqueous solubility, extensive first-pass hepatic metabolism, and low oral bioavailability. These challenges necessitate the development of advanced drug delivery systems capable of improving its systemic absorption and therapeutic performance. Nanostructured lipid carriers (NLCs) have emerged as a promising second-generation lipid-based nanocarrier system designed to overcome these limitations are composed of a blend of solid and liquid lipids stabilized by surfactants, forming an imperfect lipid matrix that enhances drug loading capacity, stability, and controlled release behavior.