The Trust Evolution: From Model Validation to Cryptographic AI Verification

Abstract

This talk given at the 2025 MDIC CM&S Summit on "Credible Models in the AI Age" traces the evolution of trust mechanisms in computational systems, from traditional model validation approaches in mechanistic modeling to emerging cryptographic verification methods for AI. We'll explore how the credibility challenge for regulators has transformed as we've moved from deterministic simulations to probabilistic AI systems, and examine how cryptographic proofs, zero-knowledge techniques, and verifiable computation are creating new pathways for establishing trust in AI outputs. By understanding this historical progression, we can better appreciate both the continuity and fundamental shifts in how we ensure reliability in our computational approaches.