Blockchain-Powered Verifiable AI Models for Medical Diagnosis

Abstract

The rapid expansion of artificial intelligence (AI) in healthcare has revolutionized diagnostic practices, enabling applications such as tumor detection in medical imaging, genomic analysis, and predictive risk modeling for early disease prevention. Despite these advancements, concerns about the opacity, trustworthiness, and auditability of AI systems remain significant barriers to clinical adoption. Medical practitioners, regulators, and patients increasingly demand systems that not only produce accurate results but also provide verifiable guarantees regarding the integrity and accountability of diagnostic processes. Blockchain technology, with its intrinsic features of decentralization, immutability, and consensus-driven validation, offers a promising solution to these concerns. This manuscript investigates the integration of blockchain-powered verifiable AI models for medical diagnosis. We present a comprehensive framework that leverages federated learning for decentralized training, blockchain for immutable storage and consensus validation, and zero-knowledge proofs for cryptographic verification of model outputs. The proposed system ensures transparent audit trails, enhances data integrity, protects patient privacy, and simplifies compliance with regulatory frameworks such as HIPAA and GDPR. Through simulated case studies in medical imaging and predictive diagnostics, we demonstrate that blockchain integration improves diagnostic verifiability, reduces susceptibility to adversarial manipulation, and fosters patient-centric trust. While slight computational latency is introduced, the trade-off is justified by significantly stronger guarantees of transparency, reproducibility, and ethical accountability. This research underscores the transformative role of blockchain in shaping the future of verifiable AI-driven healthcare, providing pathways toward more reliable, transparent, and equitable medical diagnostic ecosystems.